This volume consists of the plenary lectures and invited talks in the special session on pseudo-differential operators given at the Fourth Congress of the International Society for Analysis, Applications and Computation (ISAAC) held at York University in Toronto, August 11-16, 2003. The theme is to look at pseudo-differential operators in a very general sense and to report recent advances in a broad spectrum of topics, such as pde, quantization, filters and localization operators, modulation spaces, and numerical experiments in wavelet transforms and orthonormal wavelet bases.