I have often been asked how I first came to be a regular opium-eater, and have suffered, very unjustly, in the opinion of my acquaintance from being reputed to have brought upon myself all the sufferings which I shall have to record, by a long course of indulgence in this practice purely for the sake of creating an artificial state of pleasurable excitement. This, however, is a misrepresentation of my case. True it is that for nearly ten years I did occasionally take opium for the sake of the exquisite pleasure it gave me; but so long as I took it with this view I was effectually protected from all material bad consequences by the necessity of interposing long intervals between the several acts of indulgence, in order to renew the pleasurable sensations. It was not for the purpose of creating pleasure, but of mitigating pain in the severest degree, that I first began to use opium as an article of daily diet. In the twenty-eighth year of my age a most painful affection of the stomach, which I had first experienced about ten years before, attacked me in great strength. This affection had originally been caused by extremities of hunger, suffered in my boyish days. During the season of hope and redundant happiness which succeeded (that is, from eighteen to twenty- four) it had slumbered; for the three following years it had revived at intervals; and now, under unfavourable circumstances, from depression of spirits, it attacked me with a violence that yielded to no remedies but opium.