An archaeological manhunt is raging in the holy land -- a hunt for the historical Jesus. For Nathan Lee Swift, a young American field researcher and expectant father, the line between noble discovery and the plunder of ruins is sacred -- until the night he crosses it. At a Roman landfill beneath the crucifixion grounds known as Golgotha, Nathan Lee yields to his professor's greed and turns common grave robber. His world -- his unborn daughter -- seems lost to him.
Hundreds of miles away, on the remote Greek island of Corfu, a wealthy collector pries open his latest black-market purchase -- a fourteen-inch holy relic containing a vial of blood dating back to the first century -- and unleashes a two-thousand-year-old plague. As the pandemic explodes from the Mediterranean basin and threatens to devour humankind, Nathan Lee gets a chance at redemption. He embarks on an Odyssean journey back to the United States to find his family.
Skirting the edges of the world, Nathan Lee's path finally leads him to New Mexico, where the greatest minds of science have converged at Los Alamos to find a vaccine. There Nathan Lee meets Miranda Abbot, a nineteen-year-old prodigy. As the cure continues to elude them, Miranda launches a desperate final strategy: the use of human lab rats cloned from the year zero. Nathan Lee, the thief of bones, comes face-to-face with men made from the very relics he looted, one of whom claims to be Jesus Christ, but may also be Patient Zero.