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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.
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Previews available in: English
Subjects
Medicine, Oncology, Protein kinases, Effets physiologiques, Biochemistry, MEDICAL, Phosphoinositides, Physiological effect, Cancer Research, Proteines kinases, Phospho-inositides, Enzymes, Cellular signal transduction, Protein Kinase Inhibitors, Physiology, Signal Transduction, Inhibitors, Protein Kinases, Protein-tyrosine kinase, Therapeutic useShowing 6 featured editions. View all 6 editions?
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1
Phosphoinositide 3-Kinase in Health and Disease: Volume 2
2012, Springer Berlin / Heidelberg
in English
3642265308 9783642265303
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2
Phosphoinositide 3-kinase in Health and Disease: Volume 1
Nov 07, 2012, Springer
paperback
3642265227 9783642265228
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3
Phosphoinositide 3-kinase in Health and Disease: Volume 2
2011, Springer-Verlag Berlin Heidelberg
electronic resource :
in English
3642148158 9783642148156
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4
Phosphoinositide 3-kinase in health and disease
2010, Springer Verlag
in English
364213663X 9783642136634
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5
Phosphoinositide 3-kinase in Health and Disease: Volume 2
Nov 05, 2010, Springer
paperback
3642148174 9783642148170
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6
Phosphoinositide 3-kinase in Health and Disease: Volume 1
Nov 05, 2010, Springer
paperback
3642136648 9783642136641
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