An edition of Phosphoinositide 3-kinase in Health and Disease
(2010)
Phosphoinositide 3-kinase in health and disease
by Christian Rommel
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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.
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Previews available in: English
Subjects
Medicine, Oncology, Protein kinases, Effets physiologiques, Biochemistry, MEDICAL, Phosphoinositides, Physiological effect, Cancer Research, Proteines kinases, Phospho-inositides, Enzymes, Cellular signal transduction, Protein Kinase Inhibitors, Physiology, Signal Transduction, Inhibitors, Protein Kinases, Protein-tyrosine kinase, Therapeutic useShowing 6 featured editions. View all 6 editions?
| Edition | Availability |
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1
Phosphoinositide 3-Kinase in Health and Disease: Volume 2
2012, Springer Berlin / Heidelberg
in English
3642265308 9783642265303
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2
Phosphoinositide 3-kinase in Health and Disease: Volume 1
Nov 07, 2012, Springer
paperback
3642265227 9783642265228
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3
Phosphoinositide 3-kinase in Health and Disease: Volume 2
2011, Springer-Verlag Berlin Heidelberg
electronic resource :
in English
3642148158 9783642148156
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4
Phosphoinositide 3-kinase in health and disease
2010, Springer Verlag
in English
364213663X 9783642136634
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aaaa
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5
Phosphoinositide 3-kinase in Health and Disease: Volume 2
Nov 05, 2010, Springer
paperback
3642148174 9783642148170
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6
Phosphoinositide 3-kinase in Health and Disease: Volume 1
Nov 05, 2010, Springer
paperback
3642136648 9783642136641
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Book Details
Table of Contents
PI3K
From the Bench to the Clinic and Back
PI3K Book Introduction
PDK1: The major transducer of PI 3-Kinase actions
Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
Regulatory subunits of class IA PI3K
The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions
Phosphoinositide signalling pathways in metabolic regulation
Role of RAS in the regulation of PI 3-kinase
More than just kinases: The scaffolding function of PI3K
PI3K signalling in neutrophils
PI 3-kinase p110beta regulation of platelet integrin alphaIIbbeta3
PI3Ks in lymphocyte signalling and development
PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
Taking PI3Kdelta and PI3Kgamma one step ahead
Dual active PI3Kdelta/gamma inhibitors for the treatment of immune-mediated inflammatory diseases
Oncogenic Mutations of PIK3CA in Human Cancers
Structural Effects of Oncogenic PI3Kalpha Mutations
Comparing the roles of the p110alpha and p110beta isoforms of PI3K in signaling and cancer
Phosphatidylinositol 3-kinase (PI3K): The oncoprotein
AKT Signaling in Physiology and Disease
Faithfull modeling of PTEN loss driven diseases in the mouse
PI3K as a target for therapy in haematological malignancies
Clinical development of Phosphatidylinositol-3 kinase pathway inhibitors
New inhibitors of the PI3K-Akt-mTOR pathway: Insights into mTOR signaling from a new generation of Tor kinase domain inhibitors (TORKinibs)
Small molecule inhibitors of the PI3-kinase family
Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance
Subject index.
Edition Notes
Includes bibliographical references and index.
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| September 25, 2020 | Edited by MARC Bot | import existing book |
| August 21, 2020 | Edited by ImportBot | import existing book |
| August 2, 2020 | Edited by ImportBot | import existing book |
| June 4, 2020 | Edited by ImportBot | import existing book |
| July 6, 2019 | Created by MARC Bot | import new book |