When Vivi and Siddalee Walker, an unforgettable mother-daughter team, get into a savage fight over a New York Times article that refers to Vivi as a "tap-dancing child abuser," the fallout is felt from Louisiana to New York to Seattle. Siddalee, a successful theater director with a huge hit on her hands, panics and postpones her upcoming wedding to her lover and friend, Connor McGill. Vivi's intrepid gang of lifelong girlfriends, the Ya-Yas, sashay in and conspire to bring everyone back together.

In 1932, Vivi and the Ya-Yas were disqualified from a Shirley Temple Look-Alike Contest for unladylike behavior. Sixty years later, they're "bucking seventy" and still making waves. They persuade Vivi to send Sidda a scrapbook of girlhood mementos entitled "Divine Secrets of the Ya-Ya Sisterhood.".

With the scrapbook in hand, Sidda retreats to a cabin on Washington State's Olympic Peninsula, tormented by fear and uncertainty about the future, and intent on discovering the key to the tangle of anger and tenderness she feels toward her mother. But Vivi's album reveals more questions than answers and leads Sidda to encounter the legacy of imperfect love and the unknowable mystery of life.

With passion and a rare gift for language, Rebecca Wells moves from present to past, unraveling Vivi's life, her enduring friendships with the Ya-Yas, and the reverberations on Siddalee. The collective power of the Ya-Yas, each of them totally individual and authentic, permeates this story of a tribe of Louisiana wild women who are impossible to tame.