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Untangling the double helix
2009, Cold Spring Harbor Laboratory Press
in English
0879698632 9780879698638
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Published in
Cold Spring Harbor, N.Y
Table of Contents
An insuperable problem
Nature's solutions: the DNA topoisomerases
Breaking a DNA strand and holding onto
The broken ends
A magic swivel
Moving one DNA double helix through another
Real-time viewing of the DNA topoisomerases in action
Manifestations of DNA entanglement: replication and recombination
Manifestations of DNA entanglement: transcription and gene expression
Beyond DNA untanglement: new twists on an old
Theme
From nature's battlefields to the clinical wards
Appendix 1: identification of the covalent intermediates in topoisomerase-catalyzed reactions
Appendix 2 catalysis of dna breakage and rejoining by dna topoisomerases.
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