Editorial (Helen Castle). Introduction. Manipulation and control of Micro-Organic Matter in Architecture (Steve Pike). Contaminant (Steve Pike). Growing Semi-Living Structures: Concepts and Practices for the Use of tissue Technologies for Non-Medical Purposes. (Oron Catts and Ionat Zurr). Synthetic Neoplasms (Marcos Cruz). Density Fields in Viscous Bodies (Tobias Klein). Designer Surgeons (Marcos Cruz). Human Cloning Clinic (Nicola Haines). Cyborgian Interfaces (Marcos Cruz). Comfo-Veg Club (Peter Cook). Minimal Surface Geometry and the Green Paradigm (Sulan Kolatan). Bodies Without Organs - BwO (Francois Roche). Uto-Purification (Yukihiko Sugawara). Algaetecture and Nonsterile (Steve Pike). Living buildings (Bill Watts and Sean Affleck). Wonderwall (Ton Venhoeven). Artificial Evolution: A Hands-off Approach of Architects (Rachel Armstrong). Designer Materials for Architectu4re (Rachel Armstrong). Design for Debate (Anthony Dunne). Ethics, Architecture and Little Soft Machinery (Neil Spiller). World Expo 2008 Zaragoza (Mark Garcia).