"In recent decades, bioinformatics has emerged as a dynamic area producing a wide spectrum of new approaches and playing an important role in modern biotechnological development. This book provides an overview of novel cyberinfrastructures which are currently under development in various biomedical centers around the world. The first three chapters demonstrate various architectures for large-scale collaboration which integrate scientific accord across multiple centers. The next five chapters demonstrate modern approaches currently used in various areas of bioinformatics. The final four chapters illustrate the software challenges and strategies to resolve those challenges for large-scale biomedical informatics projects" - p. v