The Game-Players of Titan is a 1963 science fiction novel by American writer Philip K. Dick.
Pete Garden, the protagonist, is one of several residents who own large swathes of property in a depopulated, post-apocalyptic future world. These residents are organized in groups of regular competitors who play a board game called "Bluff". These contestants (or "Bindmen") stake their property, marriages and future status as eligible game players on its outcomes. Pete also experiences bipolar disorder, which may adversely affect his competence as a Game participant.

The Game is administered by amorphous, silicon-based aliens from Titan, Saturn's largest satellite. These creatures, known as the vugs, are obsessed with gambling. In addition, the Game's exogamy helps to promote human fertility after the devastation of global warfare, after satellite-borne "Henkel Radiation" weaponry from Red China sterilized much of the Earth's population. The vugs exert hegemony over Earth but do not occupy it as such. Instead, it is visualised as a paternalistic relationship. Moreover, while the vugs are telepaths, they do not allow the use of human telepathy or precognition within the context of the Game. The vugs are also involved within human society, using induced hallucination to maintain the semblance of human form. They also perpetuate the charade through the use of physical human shells or simulacra.