An edition of The Philadelphia chromosome (2013)

The Philadelphia chromosome

a mutant gene and the quest to cure cancer at the genetic level

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Cover of: The Philadelphia chromosome by Jessica Wapner
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Last edited by ImportBot
July 17, 2022 | History
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An edition of The Philadelphia chromosome (2013)

The Philadelphia chromosome

a mutant gene and the quest to cure cancer at the genetic level

by

  • ★★★★★ 5.00 ·
  • 1 Rating
  • 3 Want to read
  • 0 Currently reading
  • 1 Have read

This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this publication.

Publish Date
Publisher
The Experiment, LLC, Distributed by Workman Pub. Co., The Experiment
Language
English
Pages
303

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Previews available in: English

Subjects
Mutation (Biology), Genetic aspects, Imatinib, Cancer, Chronic myeloid leukemia, History, Research, Gene therapy, Chronic diseases, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Philadelphia Chromosome, Fusion Proteins, bcr-abl, Genetic Therapy, Myeloid Leukemia, Genetics, Therapy, Medical care, united states
People
David S. Hungerford (1938-)

Showing 3 featured editions. View all 3 editions?

Edition Availability
Cover of: The Philadelphia Chromosome
The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level
Mar 01, 2021, Highbridge Audio and Blackstone Publishing
audio cd
Libraries near you: WorldCat
Cover of: Philadelphia Chromosome
Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment
2014, Experiment LLC, The
in English
Libraries near you: WorldCat
Cover of: The Philadelphia chromosome
The Philadelphia chromosome: a mutant gene and the quest to cure cancer at the genetic level
2013, The Experiment, LLC, Distributed by Workman Pub. Co., The Experiment
in English
Libraries near you: WorldCat

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Book Details

Table of Contents

Down to the bone : February 2012
The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes"
Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man"
Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory
A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer
Survival time.

Edition Notes

"This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note.

Includes bibliographical references (p. 283-290) and index.

Published in
New York

Classifications

Dewey Decimal Class
616.99/419042
Library of Congress
RC643 .W36 2013, RC643 .W36 2014, QZ 11 AA1

The Physical Object

Pagination
xiii, 303 p., [8] p. of plates
Number of pages
303

ID Numbers

Open Library
OL27150263M
Internet Archive
philadelphiachro0000wapn
ISBN 10
1615190678, 1615191658
ISBN 13
9781615190676, 9781615191659
LCCN
2012047686, 2014005410
OCLC/WorldCat
820450840

Source records

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marc_openlibraries_sanfranciscopubliclibrary MARC record
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Library of Congress MARC record
Library of Congress MARC record
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Better World Books record
Promise Item
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July 17, 2022 Edited by ImportBot import existing book
August 18, 2021 Edited by MARC Bot import existing book
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