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This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this publication.
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Previews available in: English
Subjects
Mutation (Biology), Genetic aspects, Imatinib, Cancer, Chronic myeloid leukemia, History, Research, Gene therapy, Chronic diseases, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Philadelphia Chromosome, Fusion Proteins, bcr-abl, Genetic Therapy, Myeloid Leukemia, Genetics, Therapy, Medical care, united statesPeople
David S. Hungerford (1938-)Showing 3 featured editions. View all 3 editions?
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1
The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level
Mar 01, 2021, Highbridge Audio and Blackstone Publishing
audio cd
1665159138 9781665159135
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2
Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment
2014, Experiment LLC, The
in English
1615191976 9781615191970
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3
The Philadelphia chromosome: a mutant gene and the quest to cure cancer at the genetic level
2013, The Experiment, LLC, Distributed by Workman Pub. Co., The Experiment
in English
1615190678 9781615190676
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Book Details
Table of Contents
Edition Notes
"This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note.
Includes bibliographical references (p. 283-290) and index.
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