This Final Programmatic Environmental Impact Statement (PEIS) analyzes the potential direct, indirect, and cumulative impacts associated with the Bureau of Land Management's (BLM's) use of the herbicides aminopyralid, fluroxypyr, and rimsulfuron on the human and natural environment. These three herbicides would be added to the BLM's list of approved active ingredients and integrated into the vegetation management program that was analyzed in an earlier PEIS released in 2007. Alternatives analyzed in the PEIS include the No Action Alternative, or a continuation of use of 18 currently approved herbicides. In addition, three action alternatives were evaluated: 1) the Preferred Alternative, which would allow the BLM to use aminopyralid, fluroxypyr, and rimsulfuron in addition to the currently approved herbicides; 2) an alternative that would prohibit aerial spraying of the three new herbicides; and 3) an alternative that would only allow the BLM to add the two new herbicides without acetolactate synthase-inhibiting active ingredients (aminopyralid and fluroxypyr). Under all alternatives (including the No Action Alternative), projected maximum total use of herbicides would be the same, at 932,000 acres annually.