Investigating a role for post-translational modifications in the regulation of EBNA-1 function.

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Investigating a role for post-translational m ...
Margaret Ng Thow Hing
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January 24, 2010 | History

Investigating a role for post-translational modifications in the regulation of EBNA-1 function.

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Through binding specific recognition sites in the EBV genome, Epstein-Barr nuclear antigen (EBNA-1) viral protein performs several important functions in latent infection. The 325--376 amino acid region, which is essential for transcriptional activation and viral episome segregation functions of EBNA-1, contains four serines that have been predicted to be phosphorylated and is rich in RGG motifs that are predicted to be methylated. In addition, interactions between EBNA-1 and protein arginine methyltransferases have been identified. Through my research, I investigated a role for post-translational modifications in the regulation of EBNA-1 functions. My data suggests that serine phosphorylation of the 325--376 amino acid region of EBNA-1 may be involved in the regulation of EBNA-1 segregation activity. I also observed an alteration in EBNA-1 cellular localization upon treatment with methyl-transferase inhibitor 5'-deoxy-5'-methyl-thioadenosine (MTA), suggesting a possible role for arginine methylation in the regulation of EBNA-1 activity.

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Language
English
Pages
123

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Edition Notes

Adviser: Lori Frappier.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0786.

MICR copy on microfiche (2 microfiches).

The Physical Object

Pagination
123 leaves.
Number of pages
123

ID Numbers

Open Library
OL19512805M
ISBN 10
0612955079

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page