This study analyzes the impact of accessibility on business location and business performance in Toronto. A multinomial logit model of intra-metropolitan business location is used to assess the relative importance of accessibility variables, such as proximity to infrastructure, customers, competitors and complimentary businesses on firm location. Key accessibility variables are plotted against business performance indicators (sales and productivity) for analysis of their relationship. This study uses a detail classification of industry (4 digit SIC) so that close attention can be given to the idiosyncrasies among different industries. Specific types of business studied are: law firms, pharmacy stores and car dealerships. Results show that proximity to infrastructure is not a signification factor affecting business locations. Rather, it is the relative locations of all other socio-economic activities that matters. Further, analysis of relationship between accessibility and productivity indicates that accessibility is a necessary condition but not sufficient condition for business success.