Towards a complete intervertebral disc

modulation of the biochemical and mechanical properties of in vitro formed nucleus pulposus tissue.

  • 0 Ratings
  • 0 Want to read
  • 0 Currently reading
  • 0 Have read
Towards a complete intervertebral disc
Darla Jane Hamilton
Not in Library

My Reading Lists:

Create a new list

Check-In

×Close
Add an optional check-in date. Check-in dates are used to track yearly reading goals.
Today

  • 0 Ratings
  • 0 Want to read
  • 0 Currently reading
  • 0 Have read

Buy this book

Last edited by WorkBot
January 24, 2010 | History

Towards a complete intervertebral disc

modulation of the biochemical and mechanical properties of in vitro formed nucleus pulposus tissue.

  • 0 Ratings
  • 0 Want to read
  • 0 Currently reading
  • 0 Have read

This study aims to improve understanding of the intervertebral disc (IVD) as a complete unit. The influence of circumferential constraint provided by the annulus fibrosus is examined. Cultured bovine nucleus pulposus (NP) cells are allowed to form tissue and subjected to different degrees of circumferential constraint. As constraint increases NP cells increase gene expression of degradative molecules and decrease gene expression of matrix molecules. This leads to significantly decreased accumulation of extracellular matrix and inferior mechanical properties. Constraining NP tissue may be used as a model for IVD degeneration.Development of in vitro IVD models will lead to better understanding and treatments for disc degeneration.Creation of a novel triphasic structure consisting of calcium polyphosphate (bone substitute), cartilage, and NP tissue emulates in vivo structure by inclusion of a cartilage end plate. The structure is more adherent than NP tissue alone as demonstrated by improved tissue attachment.

Publish Date
Language
English
Pages
128

Buy this book

Book Details


Edition Notes

Advisers: Rita Kandel; Bob Pilliar.

Thesis (M.A.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0903.

MICR copy on microfiche (2 microfihces).

The Physical Object

Pagination
128 leaves.
Number of pages
128

ID Numbers

Open Library
OL19512283M
ISBN 10
0612951928

Community Reviews (0)

Feedback?
No community reviews have been submitted for this work.

Lists

This work does not appear on any lists.

History

Download catalog record: RDF / JSON
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page