Check nearby libraries
Buy this book
Telomeres are the physical ends of linear chromosomes and have an important role in protection of genomic integrity. Telomeres can be elongated by a unique ribonucleoprotein enzyme called telomerase. Telomere length maintenance is implicated in aging as well as the human diseases cancer and dyskeratosis congenita. In yeast, Est1p is known to co-mediate telomerase access and is essential for telomere length maintenance in vivo. This study characterizes a murine homologue of Est1, mEst1A. Murine embryonic stem cells with one disrupted mEst1A allele were generated, but viable null lines were not, suggesting possible lethality in the homozygous state. mEst1A mRNA was detected in most tissues examined, but not protein, perhaps due to low expression levels or inadequate antibodies. Immunoprecipitation analysis revealed an in vitro interaction of HA-tagged mEst1A with telomerase activity. These studies provide a valuable system with which to study further the role of Est1A in mammalian telomere length homeostasis.
Check nearby libraries
Buy this book
Showing 2 featured editions. View all 2 editions?
Edition | Availability |
---|---|
1 |
aaaa
Libraries near you:
WorldCat
|
2 |
zzzz
Libraries near you:
WorldCat
|
Book Details
Edition Notes
Source: Masters Abstracts International, Volume: 44-01, page: 0275.
Thesis (M.Sc.)--University of Toronto, 2005.
Electronic version licensed for access by U. of T. users.
ROBARTS MICROTEXT copy on microfiche.
The Physical Object
ID Numbers
Community Reviews (0)
Feedback?January 24, 2010 | Edited by WorkBot | add more information to works |
December 11, 2009 | Created by WorkBot | add works page |