There are two volumes. Volume-1 is the actual history of the Church in Indiana. Volume-2 is a "subscription" book consisting of biographies of the people who paid to be included.

After a few chapters on the early history of Catholic missionaries and the church in Vincennes and other French villages, Volume 1 is largely devoted to brief histories of the development of every congregation up to the 1890s , including the names of the priests who served there. There is then a chapter on education, with histories of individual parochial schools and academies. The University of Notre Dame du Lac in South Bend has a chapter-long history, followed by a chapter on monasteries and convents. The volume contains many illustrations of church buildings.

Volume 2 consists entirely of biographies, of clergy and prominent Catholics. It is heavily illustrated with portraits and views of churches.