While the short, lethal careers of serial killers such as Jeffrey Dahmer and Andrew Cunanan terrorize the public and provide morbid inspiration for the entertainment industry, few people realize that it is the female serial killer, seldom heard of, who deserves most to be feared. Murder Most Rare provides startling information about the female serial murderer, who is shown to be far more deadly and determined, difficult to apprehend, and complexly motivated than her male counterpart.

While serial murder by women is relatively rare, a surprising number of female serial killers are identified by the authors, nearly 100 in this century, with half of them having committed their crimes in America. By examining these women's backgrounds, motives and methods of killing, the book sheds new light on dozens of overlooked cases of murder and uncovers callous crimes and passions gone awry.