Overweight and obesity are commonly treated with weight-loss agents that reduce food intake through alternation to the parameters that influence meal ingestion. The mechanism of action, efficacy, and toxicological profiles of these agents are firstly assessed in animals and finally in humans. However, the currently available animal models and methods of assessment are not sufficient and sensitive enough to detect the minute changes in appetite and feeding motivation prior to the observable and quantifiable reduction in food ingestion. Hence, the current study attempts to develop and promote a novel cognitive-based protocol to assess satiety in dogs. The visuospatial memory task used in this protocol was also used to evaluate the satiability of a high-fibre diet and the anorexigenic effect of d-amphetamine. All three experiments demonstrated that the visuospatial memory task was a sensitive and valid method in assessing feeding motivation and comparing the efficacy of potential weight-reducing agents in beagle dogs.