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Autoimmune diseases are debilitating conditions that pose a significant burden worldwide. T-cells are thought to play important roles in the coordination and development of immune responses in both health and disease. A key checkpoint in the prevention of inappropriate activation of T-cells is the requirement for co-stimulation by professional APCs via receptors such as CD28. The requirement for CD28 engagement for complete activation of T-cells is lost in Cbl-b mutants, which also develop multi-organ autoimmunity and are highly-susceptible to experimental autoimmune conditions, suggesting Cbl-b may therefore play a role in the generation or maintenance of peripheral T-cell tolerance. By subjecting Cbl-b mutant mice to well-characterized in vivo tolerization protocols, we find that T-cells from these mice, unlike those from wild type mice, maintain and intensify subsequent responsiveness both in vivo and in vitro, resulting in lethality. Thus, Cbl-b is indeed essential for the induction of immunotolerance to specific antigens.
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The E3 ubiquitin ligase Cbl-b is essential for the induction of in vivo T-cell anergy.
2005
in English
0494022612 9780494022610
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The E3 ubiquitin ligase Cbl-b is essential for the induction of in vivo T-cell anergy.
2005
in English
0494022612 9780494022610
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Book Details
Edition Notes
Thesis (M.Sc.)--University of Toronto, 2005.
Electronic version licensed for access by U. of T. users.
Source: Masters Abstracts International, Volume: 44-01, page: 0308.
GERSTEIN MICROTEXT copy on microfiche (2 microfiches).
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- Created October 26, 2008
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