First Sentence

"Given that one of the cardinal features of dementia of the Alzheimer's type (DAT) is a severe memory loss accompanied by the presence of high density of senile plaques and neurofibrillary tangles in a large number of neocortical and limbic brain structures, it is imperative to develop a neurobiological model of memory to provide a theoretical framework within which one can assess potential memory dysfunctions and their neural substrates in both animals and humans."