The book is organized according to the various mammalian orders (insectivores, bats, pouched mammals, rabbits and hares, whales, and so on) under which the species accounts are given. Each species account contains concise information about identifying characteristics, geographical range, habitat, natural history, and additional factors such as longevity and economic significance. Complementing this text are more than two hundred illustrations, which include photographs, drawings, and range maps.

An eight-page selection of color plates is an especially attractive feature of the book.

In addition to the species accounts, the book's introductory sections are filled with fascinating general information on southeastern mammalogy: the study of mammals, mammal conservation, the southeastern region and mammal affinities, and the preservation of mammal specimens. A checklist of southeastern mammals, a key to the terrestrial orders, and a bibliography of selected references further enhance the usefulness of this guide.