This data report presents hydrographic (CTD) and Acoustic Doppler Current Profiler (ADCP) data from a cruise to the Continental Shelf and slope region near the Gulf of the Farallones National Marine Sanctuary during 13-18 February 1991. The study area encompassed a region from 75 km south of San Francisco (Pigeon Point) north to about 38 deg 0.0' N (Point Reyes) extending from the coast to about 90 km offshore. The sampling grid consisted of five across-shore transects 20 km apart, with nine or ten CTD stations from 5 to 15 km apart each transect. A total of forty-eight CTD's were made to within approximately 25 m of the bottom. ADCP data were collected during the occupation of the sampling grid as well during a separate ADCP survey conducted at the end of the cruise. The data are presented as vertical sections, property distributions on horizontal surfaces, and waterfall plots. Environmental Protection Agency, Farallones National Marine Sanctuary, CTD data, hydrographic data, ADCP data, shelf currents, slope currents.