Resolving the biophysics of axon transmembrane polarization in a single closed-form description.

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September 23, 2016 | History

Resolving the biophysics of axon transmembrane polarization in a single closed-form description.

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When a depolarizing event occurs across a cell membrane there is a remarkable change in its electrical properties. A complete depolarization event produces a considerably rapid increase in voltage that propagates longitudinally along the axon and is accompanied by changes in axial conductance. A dynamically changing magnetic field is associated with the passage of the action potential down the axon. Over 75 years of research has gone into the quantification of this phenomenon. To date, no unified model exist that resolves transmembrane polarization in a closed-form description. Here, a simple but formative description of propagated signaling phenomena in the membrane of an axon is presented in closed-form. The focus is on using both biophysics and mathematical methods for elucidating the fundamental mechanisms governing transmembrane polarization. The results presented demonstrate how to resolve electromagnetic and thermodynamic factors that govern transmembrane potential. Computational results are supported by well-established quantitative descriptions of propagated signaling phenomena in the membrane of an axon. The findings demonstrate how intracellular conductance, the thermodynamics of magnetization, and current modulation function together in generating an action potential in a unified closed-form description. The work presented in this paper provides compelling evidence that three basic factors contribute to the propagated signaling in the membrane of an axon. It is anticipated this work will compel those in biophysics, physical biology, and in the computational neurosciences to probe deeper into the classical and quantum features of membrane magnetization and signaling. It is hoped that subsequent investigations of this sort will be advanced by the computational features of this model without having to resort to numerical methods of analysis.

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Cover of: Resolving the biophysics of axon transmembrane polarization in a single closed-form description.
Resolving the biophysics of axon transmembrane polarization in a single closed-form description.
December 31, 2015, Journal of Applied Physics (published by the American Institute of Physics)
in English

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Table of Contents

I. INTRODUCTION AND SCOPE
II. DERIVATION OF THE CLOSED-FORM MODEL
A. Principal factor 1: Axon leaky cable conductance, Gin
B. Principal factor 2: Intracellular membrane magnetization
C. Principal factor 3: Membrane current modulation, d2I(B)/dB2
1. Premise 1
2. Premise 2
3. Premise 3
III. MATERIALS AND METHODS
IV. CONCLUSION

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Published in
Melville, NY, USA

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September 23, 2016 Edited by Robert F. Melendy, Ph.D. Just providing some more specific information here :)
September 23, 2016 Edited by Robert F. Melendy, Ph.D. Added new cover
September 23, 2016 Created by Robert F. Melendy, Ph.D. Added new book.