The propagation of fire generated smoke into a shipboard space with a geometric interference has been modeled using commercial software from the Computational Fluid Dynamics Research Corporation (CFDRC). This study was based on the dimensions of compartment 01-163-2-L and the installed ladder aboard an Arleigh Burke Class Flight IIIA Destroyer. A test model was run which validated the hindrance of fluid flow by a geometric interference. Smoke propagation scenarios were run in the shipboard compartment model. The results of the first scenario showed that smoke propagation is limited by the geometric interference. The results of the second scenario showed that smoke that is directed vertically is diverted by the geometric interference. The overall goal of this study is to show that computational fluid dynamics software can successfully model smoke propagation in shipboard spaces with a geometric interference.