The effects of aging on adult hippocampal neurogenesis in rats.

The effects of aging on adult hippocampal neu ...
Heather McDonald, Heather McDo ...
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Last edited by WorkBot
January 31, 2010 | History

The effects of aging on adult hippocampal neurogenesis in rats.

This study investigated age-related changes in hippocampal neurogenesis, as well as possible associations between new hippocampal cells and learning and memory impairment during aging. 38-day and 12-month old, male Sprague-Dawley rats were injected with 5-bromo-2'-deoxyuridine (BrdU) in order to label cells dividing in the dentate gyrus, and to follow their fates. Examined at eight time points following injection, aging rats showed a 90% decrease in proliferating cells, but similar proportions of surviving, differentiating, and maturing neurons relative to young. These results indicate that hippocampal neurogenesis, although it occurs on a drastically reduced scale relative to young levels, continues to proceed normally in aging rats. Further, spatial learning following the birth of new granule cells did not appear to directly affect or correlate with cell survival in aging rats. Decreased proliferation will not inevitably lead to deficits in learning, but the new hippocampal cells may be important for long-term memory formation.

Publish Date
Language
English
Pages
146

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Edition Notes

Adviser: J. M. Wojtowicz.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0791.

MICR copy on microfiche (2 microfiches).

The Physical Object

Pagination
146 leaves.
Number of pages
146

ID Numbers

Open Library
OL19512906M
ISBN 10
0612955672

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January 31, 2010 Edited by WorkBot add more information to works
December 9, 2009 Created by WorkBot add works page