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January 24, 2010 | History

Production, purification, and inhibition analysis of human maltase-glucoamylase using a Drosophila expression system 1 edition

Production, purification, and inhibition analysis of human maltase-glu ...
Elena Jane Rossi

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Production, purification, and inhibition analysis of human maltase-glucoamylase using a Drosophila expression system.

Published 2005 .
Written in English.

About the Book

Maltase-glucoamylase (MGA) is an enzyme of glycoside hydrolase Family 31. It is an alpha-glucosidase anchored in the membrane of small intestinal epithelial cells responsible for the final step of mammalian starch digestion causing the release of glucose. Inhibitors targeting MGA and other alpha-glucosidases delay glucose production following digestion and are currently used in treatment of Type II diabetes. In an effort to discover new inhibitors that may aid in diabetes treatment and prevention, analogs of known inhibitors are being designed and synthesized. This thesis reports the use of Drosophila tissue culture for production and purification of active human recombinant MGA suitable for structural, kinetic and inhibition studies. Four promising inhibitors were discovered from a group of prospective inhibitors modeled after salacinol, a naturally occurring alpha-glucosidase inhibitor, and miglitol, a currently prescribed anti-diabetic. Future work will focus on the structural analysis of MGA as well as drug design for new anti-diabetics.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0779.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
96 leaves.
Number of pages
96

ID Numbers

Open Library
OL19217950M
ISBN 10
0494075465

History

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page