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January 24, 2010 | History

Modulation of myocardial contractility by angiotensin II in the whole murine heart 1 edition

Modulation of myocardial contractility by angiotensin II in the whole ...
Mikin M. Patel

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Modulation of myocardial contractility by angiotensin II in the whole murine heart.

Published 2005 .
Written in English.

About the Book

We examined acute and chronic effects of Ang II on myocardial contractility. Acute Ang II infusion has transient negative inotropic effects on the myocardium. This can be segregated into vascular dependent and direct effects. Direct negative inotropic effects of Ang II are linked to NAD(P)H oxidase activation and subsequent superoxide release. Conversely, to deduce long term effects of Ang II on the myocardium, we obtained a mouse model (Angiotensin Converting Enzyme 2 (ACE2) knockout mice) with increased Ang II levels in the heart, kidneys and plasma. We observed that ACE2 knockout had persistent depressed intrinsic and in vivo contractility and depressed intrinsic coronary flow (when heart weights are included in the calculation). Therefore this thesis reveals that in the mouse, Ang II either through acute or chronic experimental situations has negative inotropic effects on contractility and these effects are mediated either through vascular dependent or direct effects of Ang II.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0736.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
101 leaves.
Number of pages
101

ID Numbers

Open Library
OL19217815M
ISBN 10
0494074981

History

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page