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January 24, 2010 | History

TBI and depression 1 edition

TBI and depression
Florance Chan

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TBI and depression
the role of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism.

Published 2005 .
Written in English.

About the Book

The relationship between depression following traumatic brain injury (TBI), antidepressant treatment response and short (s) or long (l) alleles of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism was examined. Of 156 mild-to-moderate TBI patients (96M, 50F; 34.4+/-16.9 years; 5-HTTLPR: 27.4% s/s, 50.7% s/l, or 21.9% l/l), depressed (n=34) and non-depressed (n=112) were similar in genotype frequencies (p>.05). While responders (n=5) and non-responders (n=14) to citalopram treatment (20 mg/day for 6 weeks) did not differ in genotype frequencies (p>.05), the s/s group had a smaller response compared to the l-allele carriers (HAMD change s/s: -4.9+/-6.5 vs. s/l & l/l: -9.5+/-4.9; p=.097). Neuroticism (p=.001), low extrovertness (p=.024), and post-concussion somatic symptoms (p<.001) were strong predictors of depression chi2=71.0, p<.001). These results suggest that the 5-HTTLPR polymorphism does not strongly influence risk of depression post-TBI, but the s/s genotype may be associated with poorer citalopram response.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0828.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

138 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page