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January 24, 2010 | History

Accessory protein-like is essential for IL-18-mediated signaling 1 edition

Accessory protein-like is essential for IL-18-mediated signaling
Heidi Cheung

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Accessory protein-like is essential for IL-18-mediated signaling.

Published 2005 .
Written in English.

About the Book

Interleukin 18 (IL-18) is an essential cytokine for both innate and adaptive immunity. IL-18 signals through binding to IL-18 receptor alpha (IL-18R), which contains sequence homology to IL-1R and Toll-like receptors (TLRs). While the accessory protein AcP is required for IL-1R signaling, other accessory proteins have roles in regulating TLR signaling. An ACP-like molecule (AcPL) has been identified with the ability to cooperate with IL-18Ralpha in vitro, however, its physiological function remains unknown. Here we demonstrate that IL-18 signals are abolished in AcPL-deficient mice and cells. AcPL-deficient splenocytes fail to respond to IL-18-induced proliferation and interferon-gamma production. AcPL-deficient Th1 cells, dendritic cells and neutrophils also have impaired IL-18-induced activation. Furthermore, AcPL-deficient mice show impaired IL-18-induced NK cytotoxicity. AcPL, however, is dispensable for the activation or inhibition of IL-1R and the various TLR signals that we study. These results suggest that AcPL is a specific cell surface receptor essential for IL-18 signaling.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0740.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

66 leaves.
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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page