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January 24, 2010 | History

Characterization of the type 1 interferon response during coronavirus infection 1 edition

Characterization of the type 1 interferon response during coronavirus ...
Joanna Zorzitto

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Characterization of the type 1 interferon response during coronavirus infection.

Published 2005 .
Written in English.

About the Book

SARS is a new human infectious disease with significant morbidity and mortality. A novel coronavirus (CoV) has been identified as the agent responsible. Interferon (IFN)-alpha's exhibit a critical role in host resistance to viral infection and in vitro experiments show that IFNs inhibit the SARS-CoV. IFN alfacon-1 is a synthetic IFN-alpha shown to be more potent than other type 1 IFNs. A pilot study was conducted in our laboratory to evaluate the potential clinical benefit and safety of IFN alfacon-1 in SARS treatment. Clinical results suggest that use of IFN alfacon-1 improved disease outcomes. To understand the role of IFN alfacon-1 against the SARS-CoV we studied gene expression profiles in the PBMC of SARS patients. We observe IFN-specific regulated gene expression, possibly associated with reduced viral load, and improved disease outcomes. In parallel, using the mouse CoV, MHV-1, we provide insights into IFN-activated signaling pathways that confer antiviral activity.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0814.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
143 leaves.
Number of pages
143

ID Numbers

Open Library
OL19217174M
ISBN 10
049407325X

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page