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January 24, 2010 | History

Role of endoglin in TGF-[beta] signalling in endothelial cells 1 edition

Role of endoglin in TGF-[beta] signalling in endothelial cells
Kirishanthy Kathirkamathamby

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Role of endoglin in TGF-[beta] signalling in endothelial cells.

Published 2005 .
Written in English.

About the Book

Endoglin, a transforming growth factor beta (TGF-beta) co-receptor, modulates TGF-beta responses, which in endothelial cells are mediated via ALK5 and ALK1 pathways. Since mutations in the ENG or ALK1 genes are associated with hereditary hemorrhagic telangiectasia, we hypothesized that endoglin preferentially modulates the ALK1 pathway. We studied the expression of downstream target genes of both pathways in endothelial cells derived from Endoglin null (Eng -/-) and control (Eng+/+) embryos, and showed that Eng-/- cells express higher basal levels of ALK1 regulated Smad6, Smad7, and Id1 mRNA. Transfection experiments using ALKI and ALK5 reporter genes confirmed increases in ALK1 mediated TGF-beta responses. Higher levels of ALK5 were observed, supporting the concept that the ALK1 receptor complex requires ALK5 for activity. Our data implicate endoglin as a critical player in maintaining the balance of TGF-beta pathways in endothelial cells and vascular homeostasis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0763.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

73 leaves.
Number of pages

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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page