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Physiologically-based pharmacokinetic modelling of L-asparaginase 1 edition

Physiologically-based pharmacokinetic modelling of L-asparaginase
Krista Lyn Traynor


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Physiologically-based pharmacokinetic modelling of L-asparaginase.

Published 2005 .
Written in English.

About the Book

L-asparaginase (ASNase) is a standard agent in the treatment of acute lymphocytic leukemia, but its mechanism of elimination has not yet been determined. Possible methods include hepatic and renal clearance, although renal clearance has been deemed unlikely. A physiologically-based pharmacokinetic model, including plasma, liver, kidney, muscle and gastrointestinal tract compartments, was constructed for ASNase to study the factors that affect its elimination, and to determine if renal clearance can be ruled out. Simulations were performed for hepatic and renal clearances alone and hepatic and renal clearances together. The model was fit to animal data to estimate the tissue-to-plasma partition coefficients and clearance rates. The optimal partition coefficients were 0.01-0.077 for the liver, kidneys and gastrointestinal tract, and 0.001-0.0077 for the muscles. Based on the model, the following methods of ASNase elimination are possible: (1) hepatic only, (2) hepatic and renal, (3) renal only and (4) other methods not considered here.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0970.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

123 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page