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January 24, 2010 | History

Utilizing murine hepatitis virus, a known coronavirus, to establish a SARS-like small animal model 1 edition

Utilizing murine hepatitis virus, a known coronavirus, to establish a ...
Nadine Jacqueline De Albuquerq ...

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Utilizing murine hepatitis virus, a known coronavirus, to establish a SARS-like small animal model.

Published 2006 .
Written in English.

About the Book

To establish a model for SARS, female Balb/cJ mice were inoculated with five strains of MHV intranasally (105 PFU/mouse). MHV-1-infected A/J mice developed pulmonary edema, hyaline membranes and alveolar exudates similar to SARS lung disease in humans and all infected mice died by day 8 p.i. By real-time RT-PCR, susceptible A/J mice developed a reduced type I interferon response in comparison to C57BL/6 mice whereas significantly higher cytokine levels, particularly macrophage chemoattractant protein-1 (MCP-1) were seen in A/J mice compared to resistant C57BL/6 mice. A/J mice vaccinated with MHV-3 and then subsequently challenged with MHV-1 all survived infection. These studies describe a potentially useful small animal model of human SARS, which can now be utilized to define the immunopathology of SARS and to examine treatment strategies.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2722.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
131 leaves.
Number of pages
131

ID Numbers

Open Library
OL19215831M
ISBN 13
9780494163733

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page