This Master's thesis examined the role of work stress and sex differences in the chronic pain-depression association. Using the Canadian Community Health Survey (CCHS) Cycle 1.1, of 78,593 working individuals, 8% reported having major depression versus 12% in the sample with chronic pain. Both depression and comorbid chronic pain and depression were twice as prevalent in women than in men. Unexpectedly, overall work stress, decision authority, or psychological demands did not moderate the chronic pain and depression association. There was a trend towards poor skill discretion as a moderating variable of chronic pain and depression. No sex effects were observed for any of the domains of work stress as a moderating variable in the chronic pain-depression link. In terms of the etiology and management of depression, the impact of work stress alone and the potential role of poor skill discretion in those individuals with comorbid chronic pain, should be considered.