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January 24, 2010 | History

Probing the behaviour of the subharmonic energy from microbubbles at high ultrasound frequencies 1 edition

Probing the behaviour of the subharmonic energy from microbubbles at h ...
Kevin Cheung

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Probing the behaviour of the subharmonic energy from microbubbles at high ultrasound frequencies.

Published 2006 .
Written in English.

About the Book

Ultrasound contrast agents comprised of microbubbles less than 5mum in diameter have been demonstrated to scatter subharmonic energy at one half the driving frequency. At ultrasound frequencies in the 20-40MHz range, the subharmonic offers the potential to differentiate the blood in the microcirculation from the surrounding tissue. It is unknown whether current contrast agents, manufactured to be resonant at clinical frequencies, are ideal for subharmonic imaging at higher frequencies. Numerical simulations of the Keller-Miksis model and experimental investigations of Definity microbubbles support the hypothesis that off-resonant bubbles, excited at their second harmonic, may be primarily responsible for the observed subharmonic energy. The optimal bubble size and transmit conditions for the generation of coherent subharmonics in vitro were also determined. Definity is a suitable ultrasound contrast agent for subharmonic imaging at 20MHz with peak-negative pressures between 380-590kPa and pulses greater than or equal to 4-cycles in duration.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2726.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
78 leaves.
Number of pages
78

ID Numbers

Open Library
OL19215090M
ISBN 13
9780494161562

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page