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Last edited by WorkBot
January 24, 2010 | History

A modular vascularized tissue engineering construct containing smooth muscle cells and endothelial cells 1 edition

A modular vascularized tissue engineering construct containing smooth ...
Brendan Martin Pue-Bun Leung

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A modular vascularized tissue engineering construct containing smooth muscle cells and endothelial cells.

Published 2006 .
Written in English.

About the Book

A modular tissue engineered construct was fashioned to incorporate relevant cells and geometry to create functional vasculature. Endothelial cells (EC) were seeded on collagen cylinders (modules) containing encapsulated vascular smooth muscle cells (SMC) and randomly packed into a column, forming flow channels between the modules. This project aimed to establish and characterize EC-SMC interactions. Modules encapsulated with SMC displayed their characteristic morphology at seeding densities above 106 cells/mL collagen. Embedding umbilical vein smooth muscle cells (UVSMCs) cultured with 10% FBS (PM) showed an adverse effect on surface seeded EC junction morphology compared to EC seeded on collagen-only modules. Conversely, embedding SMCs cultured in serum-free medium (QM) improved EC junction morphology. Collagen contraction was only observed in modules embedded with PM-SMC. This suggests that embedded SMC phenotype plays an important role in surface seeded EC junction morphology, and that the response can be modulated by SMC culture medium serum concentration.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2876.

Thesis (M.A.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
88 leaves.
Number of pages
88

ID Numbers

Open Library
OL19214624M
ISBN 13
9780494160688

History

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page