At a club in Missing Mile, N.C., the children of the night gather, dressed in black, looking for acceptance. Among them are Ghost, who sees what others do not. Ann, longing for love, and Jason, whose real name is Nothing, newly awakened to an ancient, deathless truth about his father, and himself.
Others are coming to Missing Mile tonight. Three beautiful, hip vagabonds - Molochai, Twig, and the seductive Zillah, whose eyes are as green as limes are on their own lost journey, slaking their ancient thirst for blood, looking for supple young flesh.

They find it in Nothing and Ann, leading them on a mad, illicit road trip south to New Orleans. Over miles of dark highway, Ghost pursues, his powers guiding him on a journey to reach his destiny, to save Ann from her new companions, to save Ann from her new companions, to save Nothing from himself...

Lost Souls is a 1992 horror novel by American writer Poppy Z. Brite, his first one. It is the only novel-length adventure of Brite's 'Steve and Ghost' characters, popularized in numerous short stories. The novel is an extended version of the short story "*The Seed of Lost Souls*".