Eli Silver is a pediatrician in Upstate New York who has accidentally let his only child die. The Sorensons are a childless couple who move from house to house, rebuilding old structures in an effort to rebuild their lives. Elizabeth Bean is a working woman-- unmarried, pregnant, and determined to bear her child. The lives of these people intersect, and eventually interlock, through circumstances that involve both the vagaries of bodily functions and emotional extremes, and the love of parents for children and of men and women for each other.