The play is set in a handsomely appointed apartment in an unnamed American city. The apartment belongs to an apparently contented young couple: stay-at-home dad Clay and his high-flying lawyer wife Kelly. The play takes place in two separate time frames, at two gatherings spliced together for dramatic effect. One is a Thanksgiving holiday dinner, at which Clay and Kelly are joined by Clay's plastic-surgeon brother Cash, his Eastern European girlfriend Kalina, and Clay's mother Carol. During the dinner it is revealed that Clay and Kelly's toddler daughter Kayla is suffering from an uncomfortable genital rash of unknown and possibly sinister cause.