At Halloween, Salem, Massachusetts, is a hot spot for Witch and tourist alike. But when a murder spree begins, a cop and scientist must team up to find the killer before a media circus unleashes, panic ensues, and more victims are killed. Forensic anthropologist Matt Lowell and Massachusetts State Police Trooper Leigh Abbott are called in to investigate burned remains following a fire in a historic antique shop. As Matt, Leigh and their team of graduate students investigate the death, clues point to Salem's traditional Witchcraft community. However, having dabbled in the Craft as a teenager, Leigh is skeptical that someone who has sworn an oath of good to all and harm to none would commit premeditated murder, let alone kill in such a vicious way. A second body is found in a similar fire and the team begins to suspect that coven members are being framed. Now they must solve the murders before 100,000 tourists overrun Salem for what could be the deadliest Halloween of their lives.