This book constitutes the refereed proceedings of the 22nd European Symposium on Programming, ESOP 2013, held as part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2013, which took place in Rome, Italy, in March 2013. The 31 papers, presented together with a full-length invited talk, were carefully reviewed and selected from 120 full submissions. The contributions have been organized according to ten topical sections on programming techniques; programming tools; separation logic; gradual typing; shared-memory concurrency and verification; process calculi; taming concurrency; model checking and verification; weak-memory concurrency and verification; and types, inference, and analysis.