Current trends in monoclonal antibody development and manufacturing
by Steven J. Shire
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| Edition | Availability |
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1
Current Trends in Monoclonal Antibody Development and Manufacturing
2012, Springer New York
in English
1461424917 9781461424918
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2
Current trends in monoclonal antibody development and manufacturing
2010, Springer, AAPS Press
in English
0387766421 9780387766423
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3
Current Trends in Monoclonal Antibody Development and Manufacturing
Nov 13, 2009, Springer
paperback
0387568263 9780387568263
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Book Details
Table of Contents
1. Introduction / Wayne R. Gombotz and Steven J. Shire
pt. I. Design of therapeutic MABS. 2. CDR repair: a novel approach to antibody humanization / Mark S. Dennis
3. Nanobodies, single-domain antigen-binding fragments of camelid heavy-chain antibodies / Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans, and Dirk Saerens
pt. II. Expression and production of MABS. 4. GPEx® a flexible method for the rapid generation of stable, high expressing, antibody producing mammalian cells lines / Gregory T. Bleck
5. Advancing our cell culture platform: incorporating lessons learned and new technologies / Carole Heath
pt. III. Recovery and purification. 6. Addressing changes associated with technology transfer: a case study / Michele M. Myers ... [et al.]
7. Concepts for disposables in biopharmaceutical manufacture / Joachim K. Walter and Uwe Gottschalk
pt. IV. Formulation and delivery. 8. Formulation and delivery issues for monoclonal antibody therapeutics / Ann L. Daugherty and Randall J. Mrsny
9. Challenges in the development of high protein concentration formulations / Steven J. Shire, Zahra Shahrock, and Jun Liu.
10. Protein immobilization by crystallization and precipitation: an alternative to lyophilization / Karoline Bechtold-Peters
pt. V. Analytics and specification setting for MABS. 11. Characterizing high affinity antigen/antibody complexes by kinetic and equilibrium based methods / Andrew W. Drake, David G. Myszka, and Scott L. Klakamp
12. Analytical characterization of monoclonal antibodies: linking structure to function / Reed J. Harris ... [et al.]
13. Analysis of irreversible aggregation, reversible self-association and fragmentation of monoclonal antibodies by analytical ultracentrifugation / James D. Andya, Jun Liu, and Steven J. Shires
14. Biophysical signatures of monoconal antibodies / N. Harn ... [et al.]
pt. VI. Pharmacokinetics and immunogenicity. 15. Impact of Fc glycosylation on monoclonal antibody effector functions and degradation by proteases / T. Shantha Raju
16. Immunogenicity assessment of antibody therapeutics / P. stas, Y. Gansemans, and I. Lasters
pt. VII. Armed antibodies and new classes of antibodies. 17. Production of monoclonal antibodies in E. coli / Dorothea E. Reilly and Daniel G. Yansura
18. Recent advances in the use of antibody drug conjugates for cancer theapy / Peter D. Senter
19. Antibody radiolabeling / Corinne Bensimon and Russell Redshaw.
Edition Notes
Includes bibliographical references and index.
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