MARC Record from marc_nuls

LEADER: 02510cam 2200385 i 4500
001 9925203907701661
005 20150818050628.0
008 150519s2015 enka b 001 0 eng
019 $a917213408
020 $a9780199688739
020 $a0199688737
035 $a99963972508
035 $a(OCoLC)909474054$z(OCoLC)917213408
035 $a(OCoLC)ocn909474054
040 $aNLM$beng$erda$cNLM$dYDXCP$dCDX$dEQO$dABG$dILC$dIQU$dVP@
042 $anlmcopyc
050 4 $aQH447$b.P37 2015
082 04 $a572.86$223
082 04 $a611/.0181663$223
100 1 $aParrington, John,$eauthor.
245 14 $aThe deeper genome :$bwhy there is more to the human genome than meets the eye /$cJohn Parrington.
250 $aFirst edition.
264 1 $aOxford, United Kingdom ;$aNew York, NY :$bOxford University Press,$c2015.
300 $av, 246 pages :$billustrations ;$c24 cm
336 $atext$2rdacontent
337 $aunmediated$2rdamedia
338 $avolume$2rdacarrier
504 $aIncludes bibliographical references (pages 210-236) and indexes.
505 0 $aIntroduction : How the genome lost its junk -- The inheritors -- Life as a code -- Switches and signals -- The spacious genome -- RNA out of the shadows -- It's a jungle in there! -- The genome in 3D -- The jumping genes -- The marks of Lamarck -- Code, non-code, garbage, and junk -- Genes and disease -- What makes us human? -- The genome that became conscious -- Conclusion : The case for complexity.
520 $aAs the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way... but the emerging picture is if anything far more exciting. Parrington gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species.
650 0 $aHuman genome.
650 0 $aGenomes.
650 0 $aDNA.
947 $hCIRCSTACKS$r31786103004898
980 $a99963972508