MARC Record from Library of Congress

LEADER: 02681nam a22003018a 4500
001 2011044253
003 DLC
005 20111027112015.0
008 111025s2011 nju b 001 0 eng
010 $a 2011044253
020 $a9780470878279 (cloth)
035 $a(DNLM)101571779
040 $aDNLM/DLC$cDLC
042 $apcc
060 10 $aQV 55
082 00 $a338.4/76151$223
245 00 $aDrug repositioning :$bbringing new life to shelved assets and existing drugs /$cedited by Michael J. Barratt, Donald Frail.
260 $aHoboken :$bJohn Wiley & Sons,$cc2011.
263 $a1206
300 $ap. ;$ccm.
504 $aIncludes bibliographical references and index.
505 0 $aDrug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong -- Drug repositioning efforts by non-profit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.
650 12 $aDrug Repositioning.
650 22 $aComputational Biology$xmethods.
650 22 $aDrug Industry$xeconomics.
650 22 $aPharmaceutical Preparations$xeconomics.
700 1 $aBarratt, Michael J.
700 1 $aFrail, Donald.