| Record ID | marc_dnb_202006/dnb_all_dnbmarc_20200615-4.mrc:2946328:5242 |
| Source | Deutsche Nationalbibliothek |
| Download Link | /show-records/marc_dnb_202006/dnb_all_dnbmarc_20200615-4.mrc:2946328:5242?format=raw |
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100 1 $0(DE-588)139572554$0https://d-nb.info/gnd/139572554$0(DE-101)139572554$aMüller, Rabea Annina$d1981-$eVerfasser$4aut$2gnd
245 10 $aPhosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex
264 1 $aFreiburg$bUniversität$c2013
300 $aOnline-Ressource
336 $aText$btxt$2rdacontent
337 $aComputermedien$bc$2rdamedia
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500 $aFrontiers in cellular neuroscience. 7 (2013), 24, DOI 10.3389/fncel.2013.00024, issn: 1662-5102
500 $aIN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
520 $aAbstract: In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase entry. Using dominant negative (dn) isoforms as well as selective pharmacological inhibitors we quantified S phase entry by nuclear labeling with bromodeoxyuridine (BrdU). Only in astroglial cells harvested from the marginal zone (MZ) of the neocortex inhibition of phosphoinositide-3-kinases reduced the nuclear labeling with BrdU, indicating that neocortical astroglial cells differ in the regulation of proliferation. The two kinase isoforms p110α and p110β were essential for S phase entry. p110α diminished the level of the p27Kip1 which inactivates the complex of cyclin E and CDK2 necessary for entry into the S phase. p110β phosphorylated and inhibited glycogen synthase kinase-3β which can prevent S-phase entry. Taken together, both isoforms mediated S phase in a subgroup of neocortical astroglial cells and acted via distinct pathways
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700 1 $0(DE-588)132713675$0https://d-nb.info/gnd/132713675$0(DE-101)132713675$aFischer, Catharina$d1977-$eVerfasser$4aut$2gnd
700 1 $0(DE-588)142756423$0https://d-nb.info/gnd/142756423$0(DE-101)142756423$aWilmes, Thomas$d1979-$eVerfasser$4aut$2gnd
700 1 $0(DE-588)1012722759$0https://d-nb.info/gnd/1012722759$0(DE-101)1012722759$aHeimrich, Bernd$d1956-$eVerfasser$4aut$2gnd
700 1 $0(DE-588)140264906$0https://d-nb.info/gnd/140264906$0(DE-101)140264906$aDistel, Vanessa$d1981-$eVerfasser$4aut$2gnd
700 1 $0(DE-588)1098215516$0https://d-nb.info/gnd/1098215516$0(DE-101)1098215516$aKlugbauer, Axel$eVerfasser$4aut$2gnd
700 1 $0(DE-588)1098570626$0https://d-nb.info/gnd/1098570626$0(DE-101)1098570626$aMeyer, Dieter K.$eVerfasser$4aut$2gnd
710 2 $0(DE-588)108196426X$0https://d-nb.info/gnd/108196426X$0(DE-101)108196426X$aAlbert-Ludwigs-Universität Freiburg$bInstitut für Experimentelle und Klinische Pharmakologie und Toxikologie$eMitwirkender$4ctb
710 2 $0(DE-588)110346129X$0https://d-nb.info/gnd/110346129X$0(DE-101)110346129X$aAlbert-Ludwigs-Universität Freiburg$bAbteilung für Neuroanatomie$eMitwirkender$4ctb
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