MARC Record from marc_columbia

LEADER: 05188cam a2200781Ma 4500
001 15062393
005 20220703231202.0
006 m o d
007 cr cn|||||||||
008 001009s1998 nyua ob 001 0 eng d
010 $z 98135840
035 $a(OCoLC)ocm45728697
035 $a(NNC)15062393
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019 $a532692883$a970775815$a984867876$a1007405488$a1053312063$a1135459027$a1197047627$a1260366576
020 $a0585266476$q(electronic bk.)
020 $a9780585266473$q(electronic bk.)
020 $z0824701305
020 $a9780429177392$q(electronic bk.)
020 $a0429177399$q(electronic bk.)
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035 $a(OCoLC)45728697$z(OCoLC)532692883$z(OCoLC)970775815$z(OCoLC)984867876$z(OCoLC)1007405488$z(OCoLC)1053312063$z(OCoLC)1135459027$z(OCoLC)1197047627$z(OCoLC)1260366576
050 4 $aRS122$b.D47 1998eb
060 4 $aQV 771$bD457 1998
070 0 $aQL55.C29$b1998
072 7 $aMED$x071000$2bisacsh
072 0 $aL110
082 04 $a615/.19$221
049 $aZCUA
245 00 $aDesign and analysis of animal studies in pharmaceutical development /$cedited by Shein-Chung Chow, Jen-pei Liu.
260 $aNew York, N.Y. :$bMarcel Dekker,$c1998.
300 $a1 online resource (x, 407 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
505 0 $aCover -- Half Title -- Title Page -- Copyright Page -- Contents -- Series Introduction -- Preface -- Contributors -- 1. Introduction -- 2. Experimental Design Principles for Animal Studies in Pharmaceutical Development -- 3. Interval Estimation with Small Samples for Median Lethal Dose or Median Effective Dose -- 4. Principles in Statistical Testing in Randomized Toxicological Studies -- 5. Subchronic Toxicity Studies -- 6. Safety Assessment in Toxicological Studies: Proof of Safety Versus Proof of Hazard -- 7. The Design of Long-Term Carcinogenicity Studies -- 8. Analysis of Long-Term Carcinogenicity Studies -- 9. Design of Developmental and Reproductive Toxicology Studies -- 10. Analysis of Reproductive and Developmental Studies -- 11. The In Vitro Ames Tests -- 12. The In Vitro Chinese Hamster Ovary Cell Mutagenesis Studies -- Index.
520 $aThis practical resource provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development - demonstrating the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products. Clarifying detailed presentations with real-world examples, Design and Analysis of Animals Studies in Pharmaceutical Development furnishes definitions, background information, and regulatory requirements...discusses statistical designs and methods for bioassay...describes techniques for estimating drug efficacy and lethal doses...illustrates statistical concepts as well as design and analysis principles for toxicology studies...shows how to assess carcinogenicity and teratology for drugs under development...details methods of analysis for in vitro Ames tests and Chinese hamster ovary cell mutagenesis studies...and more.
650 0 $aPharmacy$xResearch$xStatistical methods.
650 0 $aDiseases$xAnimal models.
650 0 $aLaboratory animals.
650 12 $aDrug Evaluation, Preclinical$xmethods
650 22 $aAnimals, Laboratory
650 22 $aStatistics as Topic$xmethods
650 22 $aToxicity Tests$xmethods
650 2 $aDisease Models, Animal
650 6 $aMaladies$xModèles animaux.
650 6 $aAnimaux de laboratoire.
650 7 $aMEDICAL$xPharmacology.$2bisacsh
650 7 $aDiseases$xAnimal models.$2fast$0(OCoLC)fst00895160
650 7 $aLaboratory animals.$2fast$0(OCoLC)fst00990395
650 7 $aPharmacy$xResearch$xStatistical methods.$2fast$0(OCoLC)fst01060321
650 7 $aPréparations pharmaceutiques$xNormes de référence.$2fmesh
650 7 $aChimie pharmaceutique$xMéthodes.$2fmesh
650 7 $aModèles animaux de maladie humaine.$2fmesh
650 7 $aAnimaux de laboratoire.$2fmesh
650 7 $aMédicaments$xConception.$2ram
650 7 $aMaladies$xModèles animaux.$2ram
650 7 $aThérapeutique expérimentale.$2ram
655 0 $aElectronic books.
655 4 $aElectronic books.
700 1 $aChow, Shein-Chung,$d1955-
700 1 $aLiu, Jen-pei,$d1952-
776 08 $iPrint version:$tDesign and analysis of animal studies in pharmaceutical development.$dNew York, N.Y. : Marcel Dekker, 1998$z0824701305$w(DLC) 98135840$w(OCoLC)38745579
830 0 $aBiostatistics (New York, N.Y.) ;$v1.
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio15062393$zTaylor & Francis eBooks
852 8 $blweb$hEBOOKS