MARC Record from marc_columbia

LEADER: 04365cam a2200661 i 4500
001 12200408
005 20161123123627.0
008 140723s2014 enk b 001 0 eng d
015 $aGBB497253$2bnb
016 7 $a101660952$2DNLM
016 7 $a016863357$2Uk
019 $a881206130$a904326019$a935948534
020 $a9781472910516$q(hardback)
020 $a1472910516$q(hardback)
020 $a9781472913203$q(trade paperback)
020 $a1472913205$q(trade paperback)
020 $z9781472910530$q(ebook)
029 0 $aNLM$b101660952
029 1 $aAU@$b000053772581
029 1 $aAU@$b000053854090
029 1 $aAU@$b000055135928
029 1 $aNLGGC$b400611732
029 1 $aNZ1$b15726063
029 1 $aNZ1$b15779235
029 1 $aUKBOR$b135016002
029 1 $aUKDEL$b135016002
029 1 $aUKTLS$b135016002
029 1 $aUNITY$b135016002
029 1 $aNZ1$b1705988
035 $a(OCoLC)ocn890394230
035 $a(OCoLC)890394230$z(OCoLC)881206130$z(OCoLC)904326019$z(OCoLC)935948534
035 $a(NNC)12200408
040 $aUKMGB$beng$erda$cNLM$dUKMGB$dCDX$dSINLB$dYDXCP$dLTSCA$dBTCTA$dBDX$dABG$dIH7$dOCLCF$dJBL$dGTA$dCUX$dVP@$dCGN$dUAB$dOCLCO$dOCLCQ$dOCLCO$dCGN$dOCL
042 $anlmcopyc
050 14 $aRC268.44.P16$bA76 2014
060 00 $a2015 G-005
060 10 $aQZ 202
082 04 $a616.994042$223
100 1 $aArmstrong, Sue,$d1952-$eauthor.
245 10 $aP53 :$bthe gene that cracked the cancer code /$cSue Armstrong.
246 30 $aGene that cracked the cancer code
264 1 $aLondon :$bBloomsbury Sigma,$c2014.
300 $a287 pages ;$c22 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aBloomsbury sigma series ;$vbook 2
504 $aIncludes bibliographical references (pages 269-277) and index.
505 0 $aFlesh of our own flesh -- The enemy within -- Discovery -- Unseeable biology -- Cloning the gene -- A case of mistaken identity -- A new angle on cancer -- p53 reveals its true colours -- Master switch -- 'Guardian of the genome' -- Of autumn leaves and cell death -- Of mice and men -- The guardian's gatekeeper -- The smoking gun -- Following the fingerprints -- Cancer in the family? -- The Tropeiro connection? -- Jekyll and Hyde -- Cancer and ageing : a balancing act? -- The treatment revolution.
520 $aAll of us have lurking in our DNA a most remarkable gene, which has a crucial job - it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures - the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge. This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives. -- Publisher description.
650 0 $ap53 antioncogene.
650 0 $aCancer$xGenetic aspects.
650 12 $aGenes, p53.
650 12 $aNeoplasms$xgenetics.
650 7 $aCancer$xGenetic aspects$2fast$0(OCoLC)fst00845368
650 7 $ap53 antioncogene.$2fast$0(OCoLC)fst01185032
830 0 $aBloomsbury sigma series ;$vbk. 2.
852 00 $bbar$hRC268.44.P16$iA76 2014