MARC Record from marc_columbia

LEADER: 04236cam a2200601 i 4500
001 11819428
005 20160420174623.0
008 150107s2015 nyua b 001 0 eng d
010 $a 2014955417
016 7 $a101657482$2DNLM
019 $a913091213$a935948857
020 $a9780231170840$q(hardback)
020 $a023117084X$q(hardback)
020 $z9780231539418 (e-book)
029 0 $aNLM$b101657482
035 $a(OCoLC)ocn899332106
035 $a(OCoLC)899332106$z(OCoLC)913091213$z(OCoLC)935948857
035 $a(NNC)11819428
040 $aYDXCP$beng$erda$cNLM$dYDXCP$dBDX$dBTCTA$dABG$dMNJ$dWKM$dVP@$dSHH$dZQP$dOCLCF$dGYG$dLMR$dOKJ$dZLM$dDLC
042 $anlmcopyc
050 04 $aQP624$b.C37 2015
050 14 $aQH447$b.C37 2015
060 00 $a2015 D-954
060 10 $aQU 460
082 04 $a572.86$223
100 1 $aCarey, Nessa,$eauthor.
245 10 $aJunk DNA :$ba journey through the dark matter of the genome /$cNessa Carey.
264 1 $aNew York :$bColumbia University Press,$c[2015]
300 $aviii, 340 pages :$billustrations ;$c24 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
504 $aIncludes bibliographical references (pages [289]-328) and index.
505 0 $aAn introduction to genomic dark matter -- Why dark matter matters -- When dark matter turns very dark indeed -- Where did all the genes go? -- Outstaying an invitation -- Everything shrinks when we get old -- Two is the perfect number -- Painting with junk -- Playing the long game -- Adding colour to the dark matter -- Why parents love junk -- Junk with a mission -- Switching it on, turning it up -- No man's land -- Project ENCODE : Big Science comes to junk DNA -- Headless queens, strange cats, and portly mice -- Lost in translation -- Why LEGO is better than Airfix -- Mini can be mighty -- The drugs do work (sometimes) -- Some light in the darkness -- Appendix. Human diseases in which junk DNA has been implicated.
520 $a"For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Our increasing knowledge of junk DNA has led to innovative research and treatment approaches that may finally ameliorate some of these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have endangered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field." -- Publisher's description
650 0 $aGenomics.
650 0 $aHuman genome.
650 0 $aEukaryotic cells.
650 0 $aRecombinant DNA.
650 0 $aInsertion elements, DNA.
650 0 $aNon-coding RNA.
650 0 $aGene therapy.
650 7 $aEukaryotic cells.$2fast$0(OCoLC)fst00916456
650 7 $aGene therapy.$2fast$0(OCoLC)fst00939638
650 7 $aGenomics.$2fast$0(OCoLC)fst00940228
650 7 $aHuman genome.$2fast$0(OCoLC)fst00963101
650 7 $aInsertion elements, DNA.$2fast$0(OCoLC)fst00974201
650 7 $aNon-coding RNA.$2fast$0(OCoLC)fst01741020
650 7 $aRecombinant DNA.$2fast$0(OCoLC)fst01091466
650 2 $aGenome, Human.
650 2 $aDNA.
650 2 $aGenomics.
852 00 $boff,sci$hQH447$i.C37 2015g