MARC Record from marc_columbia

LEADER: 04800cam a2200469 a 4500
001 7924155
005 20221201044509.0
008 100105t20102010flua b 001 0 eng
010 $a 2010000178
016 7 $a101522007$2DNLM
019 $a150368723
020 $a9780849390005 (hardcover : alk. paper)
020 $a0849390001 (hardcover : alk. paper)
029 1 $aNLM$b101522007
035 $a(OCoLC)ocn498973856
035 $a(OCoLC)498973856$z(OCoLC)150368723
035 $a(NNC)7924155
035 $a7924155
040 $aDNLM/DLC$cDLC$dBTCTA$dBAKER$dYDXCP$dNLM$dC#P$dOrLoB-B
042 $apcc
050 00 $aRC394.H85$bN48 2010
060 10 $aWL 390$bN4948 2010
082 00 $a616.8/51$222
245 00 $aNeurobiology of Huntington's disease :$bapplications to drug discovery /$cedited by Donald C. Lo, Robert E. Hughes.
260 $aBoca Raton :$bCRC Press/Taylor & Francis Group,$c[2010], ©2010.
300 $axx, 312 pages :$billustrations ;$c25 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
490 1 $aFrontiers in neuroscience
504 $aIncludes bibliographical references and index.
505 00 $gChapter 1.$tHuntington's Disease: Clinical Features and Routes to Therapy /$rRoger L. Albin -- $gChapter 2.$tHuntington's Disease Pathogenesis: Mechanisms and Pathways /$rVictor V. Pineda -- $gChapter 3.$tProtein Interactions and Target Discovery in Huntington's Disease /$rRobert E. Hughes -- $gChapter 4.$tTarget Validation for Huntington's Disease /$rDavid S. Howland -- $gChapter 5.$tHigh-Throughput and High-Content Screening for Huntington's Disease Therapeutics /$rBrent R. Stockwell -- $gChapter 6.$tValue of Invertebrate Genetics and Biology to Develop Neuroprotective and Preventive Medicine in Huntington's Disease /$rChristian Neri -- $gChapter 7.$tMouse Models for Validating Preclinical Candidates for Huntington's Disease /$rMichelle Gray -- $gChapter 8.$tPharmaceutical Development for Huntington's Disease /$rRobert Pacifici -- $gChapter 9.$tRNA- and DNA-Based Therapies for Huntington's Disease /$rNeil Aronin -- $gChapter 10.$tRecombinant Intrabodies as Molecular Tools and Potential Therapeutics for Huntington's Disease /$rPaul H. Patterson -- $gChapter 11.$tBiomarkers to Enable the Development of Neuroprotective Therapies for Huntington's Disease /$rH. Diana Rosas -- $gChapter 12.$tHuntington's Disease: Clinical Experimental Therapeutics /$rIra Shoulson.
520 1 $a"In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene" "Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD." "While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--BOOK JACKET.
650 0 $aHuntington's disease$xPathophysiology.
650 0 $aHuntington's disease$xMolecular aspects.
650 0 $aNeuropharmacology.$0http://id.loc.gov/authorities/subjects/sh85091157
650 12 $aHuntington Disease$xphysiopathology.$0https://id.nlm.nih.gov/mesh/D006816Q000503
650 22 $aDrug Discovery$xmethods.$0https://id.nlm.nih.gov/mesh/D055808Q000379
650 22 $aHuntington Disease$xdrug therapy.$0https://id.nlm.nih.gov/mesh/D006816Q000188
700 1 $aLo, Donald C.$0http://id.loc.gov/authorities/names/n2010180038
700 1 $aHughes, Robert E.,$cPh.D.$0http://id.loc.gov/authorities/names/n2010180145
830 0 $aFrontiers in neuroscience (Boca Raton, Fla.)$0http://id.loc.gov/authorities/names/n2004122781
852 00 $boff,hsl$hRC394.H85$iN48 2010